Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers† †Electronic supplementary information (ESI) available: Peptide synthesis, further details of PIC nanoparticle characterisation and full data from microbiology assays. See DOI: 10.1039/c6py00146g Click here for additional data file.

Analysis of enzyme-responsive peptide surfaces by Raman spectroscopy† †Electronic supplementary information (ESI) available: Detail information about materials and instrumentation, sample preparation, synthesis details and characterisation. See DOI: 10.1039/c5cc09189f Click here for additional data file.

Nanoparticle “switch-on” by tetrazine triggering† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc05118a Click here for additional data file. Click here for additional data file. Click here for additional data file.

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels-Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent d...

Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone† †Electronic supplementary information (ESI) available: Details on solid phase peptide synthesis and characterisation of all peptides can be found here, as well as experimental details on cGMP assays, aortic tensometry, islet treatment, statistics and a detailed description of modelling and simulations. See DOI: 10.1039/c6sc05044a Click here for additional data file.

pH controlled assembly of a self-complementary halogen-bonded dimer† †Electronic supplementary information (ESI) available: Details of computational methods, synthesis and characterisation data for all compounds are provided. CCDC 1488032–1488035. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03696a Click here for additional data file. Click here for additional data file.

Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates† †Electronic supplementary information (ESI) available: Supporting figures, synthesis and characterisation of the substrates, and enzymatic assays. See DOI: 10.1039/c5mb00730e Click here for additional data file.